Accuracy of eight deformable image registration (DIR) methods for tomotherapy megavoltage computed tomography (MVCT) images

INTRODUCTION The application of deformable image registration (DIR) to megavoltage computed tomography (MVCT) images benefits adaptive radiotherapy. This study aims to quantify the accuracy of DIR for MVCT images when using different deformation methods assessed in a cubic phantom and nasopharyngeal carcinoma (NPC) patients. METHODS In the control studies, the DIR accuracy in air-tissue and tissue-tissue interface areas was observed using twelve shapes of acrylic and tissue-equivalent material inserted in the phantom. In the clinical studies, the 1st and 20th fraction MVCT images of seven NPC patients were used to evaluate application of DIR. The eight DIR methods used in the DIRART software varied in (i) transformation framework (asymmetric or symmetric), (ii) DIR registration algorithm (Demons or Optical Flow) and (iii) mapping direction (forward or backward). The accuracy of the methods was compared using an intensity-based criterion (correlation coefficient, CC) and volume-based criterion (Dice's similarity coefficient, DSC). RESULTS The asymmetric transformation with Optical Flow showed the best performance for air-tissue interface areas, with a mean CC and DSC of 0.97 ± 0.03 and 0.79 ± 0.11 respectively. The symmetric transformation with Optical Flow showed good agreement for tissue-tissue interface areas with a CC of (0.99 ± 0.01) and DSC of (0.89 ± 0.03). The sequences of target domains were significantly different in tissue-tissue interface areas. CONCLUSIONS The deformation method and interface area affected the accuracy of DIR. The validation techniques showed satisfactory volume matching of greater than 0.7 with DSC analysis. The methods can yield acceptable results for clinical applications.